InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IKBKE

Summary

InnateDB Protein

IDBP-811862.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IKBKE

Protein Name

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Synonyms

IKK-E; IKK-i; IKKE; IKKI;

Species

Homo sapiens

Ensembl Protein

ENSP00000464030

InnateDB Gene

IDBG-776557 (IKBKE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 132 experimentally validated interaction(s) in this database.

Experimentally validated
Total	132 [view]
Protein-Protein	131 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007252	I-kappaB phosphorylation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032480	negative regulation of type I interferon production
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt