InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR1H3

Summary

InnateDB Protein

IDBP-811966.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1H3

Protein Name

nuclear receptor subfamily 1, group H, member 3

Synonyms

LXR-a; LXRA; RLD-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000477707

InnateDB Gene

IDBG-42877 (NR1H3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	45 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010875	positive regulation of cholesterol efflux
GO:0010887	negative regulation of cholesterol storage
GO:0030522	intracellular receptor signaling pathway
GO:0042632	cholesterol homeostasis
GO:0043031	negative regulation of macrophage activation
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0045861	negative regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0055088	lipid homeostasis
GO:0055092	sterol homeostasis
GO:0070328	triglyceride homeostasis
GO:0071222	cellular response to lipopolysaccharide
GO:0090188	negative regulation of pancreatic juice secretion
GO:0090341	negative regulation of secretion of lysosomal enzymes
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003069 Ecdysteroid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR023257 Liver X receptor

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01283
PR02034

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt