Version 5.4
Homo sapiens Protein: CDK5R2
Summary
InnateDB Protein IDBP-81216.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5R2
Protein Name cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Synonyms NCK5AI; P39; p39nck5ai;
Species Homo sapiens
Ensembl Protein ENSP00000304250
InnateDB Gene IDBG-81214 (CDK5R2)
Protein Structure
UniProt Annotation
Function Activator of CDK5/TPKII.
Subcellular Localization Cell membrane {ECO:0000269PubMed:18507738}; Lipid-anchor {ECO:0000269PubMed:18507738}; Cytoplasmic side {ECO:0000269PubMed:18507738}.
Disease Associations
Tissue Specificity Brain and neuron specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0016534 cyclin-dependent protein kinase 5 activator activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001764 neuron migration
GO:0021549 cerebellum development
GO:0021722 superior olivary nucleus maturation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0045860 positive regulation of protein kinase activity
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
Protein Structure and Domains
PDB ID
InterPro IPR004944 Cyclin-dependent kinase 5 activator
IPR013763 Cyclin-like
PFAM PF03261
PRINTS
PIRSF PIRSF009324
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13319
PhosphoSite PhosphoSite-Q13319
TrEMBL Q96G76
UniProt Splice Variant
Entrez Gene 8941
UniGene Hs.741488
RefSeq NP_003927
HUGO HGNC:1776
OMIM 603764
CCDS CCDS2427
HPRD 04790
IMGT
EMBL AC097468 BT007437 DQ307839 U34051
GenPept AAC50278 AAP36105 AAX88916 ABB96255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca