Version 5.4
Homo sapiens Gene: CDK5R2
Summary
InnateDB Gene IDBG-81214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5R2
Gene Name cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Synonyms NCK5AI; P39; p39nck5ai
Species Homo sapiens
Ensembl Gene ENSG00000171450
Encoded Proteins
IDBP-81216
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218959655-218962162
Strand Forward strand
Band q35
Transcripts
ENST00000302625 ENSP00000304250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0016534 cyclin-dependent protein kinase 5 activator activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001764 neuron migration
GO:0021549 cerebellum development
GO:0021722 superior olivary nucleus maturation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0045860 positive regulation of protein kinase activity
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000090071
View Gene Order
ENSBTAG00000031052
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt Q13319
TrEMBL Q96G76
UniProt Splice Variant
Entrez Gene 8941
UniGene Hs.158460 Hs.741488
RefSeq NM_003936
HUGO HGNC:1776
OMIM 603764
CCDS CCDS2427
HPRD 04790
IMGT
EMBL AC097468 BT007437 DQ307839 U34051
GenPept AAC50278 AAP36105 AAX88916 ABB96255
RNA Seq Atlas 8941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca