InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TWIST2

Summary

InnateDB Protein

IDBP-812219.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TWIST2

Protein Name

twist family bHLH transcription factor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000482581

InnateDB Gene

IDBG-310754 (TWIST2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010838	positive regulation of keratinocyte proliferation
GO:0032720	negative regulation of tumor necrosis factor production
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0044092	negative regulation of molecular function
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060325	face morphogenesis
GO:0061303	cornea development in camera-type eye