Version 5.4
Homo sapiens Gene: TWIST2
Summary
InnateDB Gene IDBG-310754.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TWIST2
Gene Name twist homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000233608
Encoded Proteins
IDBP-389545
twist homolog 2 (Drosophila)
IDBP-812219
twist family bHLH transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:238848032-238910543
Strand Forward strand
Band q37.3
Transcripts
ENST00000448943 ENSP00000405176
ENST00000612363 ENSP00000482581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0044092 negative regulation of molecular function
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060325 face morphogenesis
GO:0061303 cornea development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007805
View Gene Order
ENSBTAG00000021444
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001271893 NM_057179
HUGO
OMIM
CCDS CCDS46558
HPRD 09616
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca