Homo sapiens Protein: SIRT5
Summary
InnateDB Protein IDBP-812857.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT5
Protein Name sirtuin 5
Synonyms SIR2L5;
Species Homo sapiens
Ensembl Protein ENSP00000476228
InnateDB Gene IDBG-62340 (SIRT5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 72 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006342 chromatin silencing
GO:0006476 protein deacetylation
GO:0036047 peptidyl-lysine demalonylation
GO:0036048 protein desuccinylation
GO:0036049 peptidyl-lysine desuccinylation
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF02146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXA8
PhosphoSite PhosphoSite-Q9NXA8
TrEMBL A0A024R012
UniProt Splice Variant
Entrez Gene 23408
UniGene
RefSeq NP_036373
HUGO HGNC:14933
OMIM 604483
CCDS CCDS4526
HPRD
IMGT
EMBL AF083110 AK000355 AK294162 AK302467 AL441883 AM393414 BC000126 CH471087
GenPept AAD40853 AAH00126 BAA91107 BAG57485 BAG63757 CAI19837 CAI19838 CAL38292 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336