InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIRT5

Summary

InnateDB Protein

IDBP-812857.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT5

Protein Name

sirtuin 5

Synonyms

SIR2L5;

Species

Homo sapiens

Ensembl Protein

ENSP00000476228

InnateDB Gene

IDBG-62340 (SIRT5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	72 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

Biological Process

GO:0006342	chromatin silencing
GO:0006476	protein deacetylation
GO:0036047	peptidyl-lysine demalonylation
GO:0036048	protein desuccinylation
GO:0036049	peptidyl-lysine desuccinylation
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q9NXA8

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF083110 AK000355 AK294162 AK302467 AL441883 AM393414 BC000126 CH471087

GenPept

AAD40853 AAH00126 BAA91107 BAG57485 BAG63757 CAI19837 CAI19838 CAL38292 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca