InnateDB Protein
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IDBP-81573.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDC26
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Protein Name
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cell division cycle 26 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363322
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InnateDB Gene
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IDBG-81571 (CDC26)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269PubMed:18485873}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000278
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mitotic cell cycle
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GO:0007067
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mitotic nuclear division
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GO:0007094
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mitotic spindle assembly checkpoint
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GO:0030071
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regulation of mitotic metaphase/anaphase transition
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0070979
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protein K11-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR018860
Anaphase-promoting complex, subunit CDC26
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PFAM |
PF10471
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NHZ8
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PhosphoSite |
PhosphoSite-Q8NHZ8
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TrEMBL |
A0A024R832
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UniProt Splice Variant |
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Entrez Gene |
246184
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UniGene |
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RefSeq |
NP_644815
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HUGO |
HGNC:17839
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OMIM |
614533
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CCDS |
CCDS6790
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HPRD |
13012
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IMGT |
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EMBL |
AF503918
AL449305
BC042534
BC066300
CH471070
CH471090
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GenPept |
AAH42534
AAH66300
AAM34207
CAI10967
EAW83718
EAW87360
EAW87361
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