Version 5.4
Homo sapiens Protein: PFDN4
Summary
InnateDB Protein IDBP-81645.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN4
Protein Name prefoldin subunit 4
Synonyms C1; PFD4;
Species Homo sapiens
Ensembl Protein ENSP00000360473
InnateDB Gene IDBG-81643 (PFDN4)
Protein Structure
UniProt Annotation
Function Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269PubMed:9630229}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17936702}. Cytoplasm {ECO:0000269PubMed:17936702}. Mitochondrion {ECO:0000269PubMed:17936702}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016272 prefoldin complex
Protein Structure and Domains
PDB ID
InterPro IPR002777 Prefoldin beta-like
IPR009053 Prefoldin
IPR016661 Prefoldin, subunit 4
PFAM PF01920
PRINTS
PIRSF PIRSF016477
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQP4
PhosphoSite PhosphoSite-Q9NQP4
TrEMBL
UniProt Splice Variant
Entrez Gene 5203
UniGene Hs.91161
RefSeq NP_002614
HUGO HGNC:8868
OMIM 604898
CCDS CCDS13445
HPRD 05358
IMGT
EMBL AL133335 BC010953 U41816
GenPept AAB17063 AAH10953 CAI19316

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca