Homo sapiens Gene: PFDN4
Summary
InnateDB Gene IDBG-81643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN4
Gene Name prefoldin subunit 4
Synonyms C1; PFD4;
Species Homo sapiens
Ensembl Gene ENSG00000101132
Encoded Proteins
prefoldin subunit 4
prefoldin subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:54207847-54228052
Strand Forward strand
Band q13.2
Transcripts
ENST00000371419 ENSP00000360473
ENST00000441080 ENSP00000432441
ENST00000493356
ENST00000487129
ENST00000474326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016272 prefoldin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596034 Hs.91161
RefSeq NM_002623
HUGO
OMIM
CCDS CCDS13445
HPRD 05358
IMGT
EMBL
GenPept
RNA Seq Atlas