InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PANK1

Summary

InnateDB Protein

IDBP-82012.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PANK1

Protein Name

pantothenate kinase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345118

InnateDB Gene

IDBG-82008 (PANK1)

Protein Structure

UniProt Annotation

Function

Plays a role in the physiological regulation of the intracellular CoA concentration. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14523052}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle. {ECO:0000269PubMed:14523052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009108	coenzyme biosynthetic process
GO:0015937	coenzyme A biosynthetic process
GO:0015939	pantothenate metabolic process
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process