InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PANK1

Summary

InnateDB Gene

IDBG-82008.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PANK1

Gene Name

pantothenate kinase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000152782

Encoded Proteins

IDBP-82010

pantothenate kinase 1

IDBP-82012

pantothenate kinase 1

IDBP-82014

pantothenate kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:89579497-89645572

Strand

Reverse strand

Band

q23.31

Transcripts

ENST00000307534	ENSP00000302108
ENST00000342512	ENSP00000345118
ENST00000322191	ENSP00000318526
ENST00000461829
ENST00000488482

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009108	coenzyme biosynthetic process
GO:0015937	coenzyme A biosynthetic process
GO:0015939	pantothenate metabolic process
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process