InnateDB Protein
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IDBP-82113.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKNA
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Protein Name
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AT-hook transcription factor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363188
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InnateDB Gene
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IDBG-82103 (AKNA)
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Protein Structure
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Function |
Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. {ECO:0000269PubMed:11268217}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11268217}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow. {ECO:0000269PubMed:11268217}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR022150
Transcription factor, AT-hook-containing
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PFAM |
PF12443
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z591
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PhosphoSite |
PhosphoSite-Q7Z591
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80709
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UniGene |
Hs.704553
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RefSeq |
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HUGO |
HGNC:24108
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OMIM |
605729
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CCDS |
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HPRD |
16148
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IMGT |
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EMBL |
AB075848
AF286341
AK024431
AK074040
AK131082
AK160382
AL356796
AY703039
AY703043
AY703044
AY703045
BC042202
BC055285
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GenPept |
AAH42202
AAH55285
AAK83024
AAU34186
AAU34190
AAU34191
AAU34192
BAB15721
BAB84866
BAB85554
BAC85132
BAD18725
CAI16861
CAI16862
CAI16863
CAM23638
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