Version 5.4
Homo sapiens Gene: AKNA
Summary
InnateDB Gene IDBG-82103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKNA
Gene Name AT-hook transcription factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106948
Encoded Proteins
IDBP-82105
AT-hook transcription factor
IDBP-82109
AT-hook transcription factor
IDBP-82111
AT-hook transcription factor
IDBP-82113
AT-hook transcription factor
IDBP-82117
AT-hook transcription factor
IDBP-82119
AT-hook transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21606955
AKNA targeted deletion results in susceptibility to pathogen-induced systemic inflammation and causes sudden neonatal death. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21606955
[Mus musculus] Akna targeted deletion results in susceptibility to pathogen-induced systemic inflammation and causes sudden neonatal death.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:114334156-114394405
Strand Reverse strand
Band q32
Transcripts
ENST00000374088 ENSP00000363201
ENST00000307564 ENSP00000303769
ENST00000374079 ENSP00000363192
ENST00000374075 ENSP00000363188
ENST00000223791 ENSP00000223791
ENST00000312033 ENSP00000309222
ENST00000492875
ENST00000491133
ENST00000490767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039158
View Gene Order
ENSBTAG00000017306
Not yet available
Cross-References
SwissProt Q7Z591
TrEMBL
UniProt Splice Variant
Entrez Gene 80709
UniGene Hs.494895 Hs.700135 Hs.704553
RefSeq NM_030767 XM_005252243 XM_005252244 XM_005252245 XM_005252246 XM_005252247 XM_006717294 XM_006717295
HUGO HGNC:24108
OMIM 605729
CCDS CCDS6805
HPRD 16148
IMGT
EMBL AB075848 AF286341 AK024431 AK074040 AK131082 AK160382 AL356796 AY703039 AY703043 AY703044 AY703045 BC042202 BC055285
GenPept AAH42202 AAH55285 AAK83024 AAU34186 AAU34190 AAU34191 AAU34192 BAB15721 BAB84866 BAB85554 BAC85132 BAD18725 CAI16861 CAI16862 CAI16863 CAM23638
RNA Seq Atlas 80709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca