Version 5.4
Homo sapiens Protein: KCNE4
Summary
InnateDB Protein IDBP-82249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNE4
Protein Name potassium voltage-gated channel, Isk-related family, member 4
Synonyms MIRP3;
Species Homo sapiens
Ensembl Protein ENSP00000281830
InnateDB Gene IDBG-82247 (KCNE4)
Protein Structure
UniProt Annotation
Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart. {ECO:0000269PubMed:12096056}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
PFAM PF02060
PRINTS PR00168
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWG9
PhosphoSite PhosphoSite-
TrEMBL Q2N1I0
UniProt Splice Variant
Entrez Gene 23704
UniGene Hs.701703
RefSeq NP_542402
HUGO HGNC:6244
OMIM 607775
CCDS CCDS2456
HPRD 09689
IMGT
EMBL AC017014 AK294423 AK313203 AY065987 BC014429 CH471063 DQ192293 DQ784806
GenPept AAH14429 AAL49979 AAX93228 ABB00306 ABQ01241 BAG36019 BAH11761 EAW70810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca