Homo sapiens Gene: KCNE4
Summary
InnateDB Gene IDBG-82247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNE4
Gene Name potassium voltage-gated channel, Isk-related family, member 4
Synonyms MIRP3
Species Homo sapiens
Ensembl Gene ENSG00000152049
Encoded Proteins
potassium voltage-gated channel, Isk-related family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:223051814-223198399
Strand Forward strand
Band q36.1
Transcripts
ENST00000281830 ENSP00000281830
ENST00000488477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q8WWG9
TrEMBL A5H1P5 Q2N1I0
UniProt Splice Variant
Entrez Gene 23704
UniGene Hs.348522 Hs.701703
RefSeq NM_080671
HUGO HGNC:6244
OMIM 607775
CCDS CCDS2456
HPRD
IMGT
EMBL AC017014 AK294423 AK313203 AY065987 BC014429 CH471063 DQ192293 DQ784806
GenPept AAH14429 AAL49979 AAX93228 ABB00306 ABQ01241 BAG36019 BAH11761 EAW70810
RNA Seq Atlas 23704