InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFSF15

Summary

InnateDB Protein

IDBP-82300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF15

Protein Name

tumor necrosis factor (ligand) superfamily, member 15

Synonyms

TL1; TL1A; VEGI; VEGI192A;

Species

Homo sapiens

Ensembl Protein

ENSP00000363157

InnateDB Gene

IDBG-82298 (TNFSF15)

Protein Structure

UniProt Annotation

Function

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269PubMed:10597252, ECO:0000269PubMed:11911831, ECO:0000269PubMed:11923219, ECO:0000269PubMed:9872942}.

Subcellular Localization

Membrane {ECO:0000305PubMed:11911831, ECO:0000305PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305PubMed:11911831, ECO:0000305PubMed:11923219}.Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.

Disease Associations

Tissue Specificity

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269PubMed:11911831, ECO:0000269PubMed:11923219, ECO:0000269PubMed:9434163, ECO:0000269PubMed:9872942}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005123	death receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0042107	cytokine metabolic process
GO:0050715	positive regulation of cytokine secretion

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane