Homo sapiens Gene: TNFSF15
Summary
InnateDB Gene IDBG-82298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF15
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1; TL1A; VEGI; VEGI192A;
Species Homo sapiens
Ensembl Gene ENSG00000181634
Encoded Proteins
tumor necrosis factor (ligand) superfamily, member 15
tumor necrosis factor (ligand) superfamily, member 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:114784635-114806126
Strand Reverse strand
Band q32
Transcripts
ENST00000374045 ENSP00000363157
ENST00000374044 ENSP00000363156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005123 death receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0042107 cytokine metabolic process
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95150
TrEMBL D9N2U0 X6R8I9
UniProt Splice Variant
Entrez Gene 9966
UniGene Hs.23349
RefSeq NM_001204344 NM_005118
HUGO HGNC:11931
OMIM 604052
CCDS CCDS6809
HPRD
IMGT
EMBL AB542703 AB542704 AF039390 AF520785 AK291642 AL390240 AY434464 BC069435 BC074940 BC074941 BC104462 BC104463 CH471090
GenPept AAD08783 AAH69435 AAH74940 AAH74941 AAI04463 AAI04464 AAM77366 AAR98573 BAF84331 BAJ13472 BAJ13473 CAH73730 CAH73731 EAW87431
RNA Seq Atlas 9966