Version 5.4
Homo sapiens Protein: TNFSF15
Summary
InnateDB Protein IDBP-82302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF15
Protein Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1; TL1A; VEGI; VEGI192A;
Species Homo sapiens
Ensembl Protein ENSP00000363156
InnateDB Gene IDBG-82298 (TNFSF15)
Protein Structure
UniProt Annotation
Function Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269PubMed:10597252, ECO:0000269PubMed:11911831, ECO:0000269PubMed:11923219, ECO:0000269PubMed:9872942}.
Subcellular Localization Membrane {ECO:0000305PubMed:11911831, ECO:0000305PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305PubMed:11911831, ECO:0000305PubMed:11923219}.Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.
Disease Associations
Tissue Specificity Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269PubMed:11911831, ECO:0000269PubMed:11923219, ECO:0000269PubMed:9434163, ECO:0000269PubMed:9872942}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006052 Tumour necrosis factor domain
IPR006053 Tumour necrosis factor
IPR008983 Tumour necrosis factor-like domain
PFAM PF00229
PRINTS PR01234
PIRSF
SMART SM00207
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL X6R8I9
UniProt Splice Variant
Entrez Gene 9966
UniGene Hs.23349
RefSeq
HUGO HGNC:11931
OMIM 604052
CCDS
HPRD 04956
IMGT
EMBL AB542703 AB542704 AL390240
GenPept BAJ13472 BAJ13473

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca