InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNC

Summary

InnateDB Protein

IDBP-82350.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNC

Protein Name

tenascin C

Synonyms

150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C;

Species

Homo sapiens

Ensembl Protein

ENSP00000265131

InnateDB Gene

IDBG-82348 (TNC)

Protein Structure

UniProt Annotation

Function

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269PubMed:23936043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045545	syndecan binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007528	neuromuscular junction development
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0010628	positive regulation of gene expression
GO:0014012	peripheral nervous system axon regeneration
GO:0030198	extracellular matrix organization
GO:0031175	neuron projection development
GO:0042060	wound healing
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045471	response to ethanol
GO:0060447	bud outgrowth involved in lung branching
GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development
GO:0060740	prostate gland epithelium morphogenesis
GO:0071300	cellular response to retinoic acid
GO:0071305	cellular response to vitamin D
GO:0071774	response to fibroblast growth factor
GO:0071799	cellular response to prostaglandin D stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005614	interstitial matrix
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR003961 Fibronectin, type III
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF00147
PF00041
PF01108
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00186
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P24821