Homo sapiens Gene: TNC
Summary
InnateDB Gene IDBG-82348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNC
Gene Name tenascin C
Synonyms 150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C;
Species Homo sapiens
Ensembl Gene ENSG00000041982
Encoded Proteins
tenascin C
tenascin C
tenascin C
tenascin C
tenascin C
tenascin C
tenascin C
tenascin C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:115019578-115118257
Strand Reverse strand
Band q33.1
Transcripts
ENST00000350763 ENSP00000265131
ENST00000341037 ENSP00000339553
ENST00000423613 ENSP00000411406
ENST00000460345
ENST00000498724
ENST00000476680
ENST00000473855
ENST00000481475
ENST00000537320 ENSP00000443478
ENST00000542877 ENSP00000442242
ENST00000544972 ENSP00000445380
ENST00000534839 ENSP00000443469
ENST00000535648 ENSP00000438152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0045545 syndecan binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007528 neuromuscular junction development
GO:0008284 positive regulation of cell proliferation
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0010628 positive regulation of gene expression
GO:0014012 peripheral nervous system axon regeneration
GO:0030198 extracellular matrix organization
GO:0031175 neuron projection development
GO:0042060 wound healing
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045471 response to ethanol
GO:0060447 bud outgrowth involved in lung branching
GO:0060739 mesenchymal-epithelial cell signaling involved in prostate gland development
GO:0060740 prostate gland epithelium morphogenesis
GO:0071300 cellular response to retinoic acid
GO:0071305 cellular response to vitamin D
GO:0071774 response to fibroblast growth factor
GO:0071799 cellular response to prostaglandin D stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005614 interstitial matrix
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Syndecan interactions pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Alpha9 beta1 integrin signaling events
Syndecan-4-mediated signaling events
Beta3 integrin cell surface interactions
Cross-References
SwissProt P24821
TrEMBL A9YUB8 E9PC84 F5H5D6 F5H7V9 J3QSU6
UniProt Splice Variant
Entrez Gene 3371
UniGene Hs.143250 Hs.684865
RefSeq NM_002160 XM_005251975 XM_006717098 XM_006717100
HUGO HGNC:5318
OMIM 187380
CCDS CCDS6811
HPRD
IMGT
EMBL AL162425 EU295718 M24630 M55618 X56160 X78565 X80280
GenPept AAA52703 AAA88083 ABX89318 CAA39628 CAA55309 CAI15110
RNA Seq Atlas 3371