InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNC

Summary

InnateDB Gene

IDBG-82348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNC

Gene Name

tenascin C

Synonyms

150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C

Species

Homo sapiens

Ensembl Gene

ENSG00000041982

Encoded Proteins

IDBP-82350

tenascin C

IDBP-82352

tenascin C

IDBP-378707

tenascin C

IDBP-597861

tenascin C

IDBP-600023

tenascin C

IDBP-586249

tenascin C

IDBP-586712

tenascin C

IDBP-587368

tenascin C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:115019578-115118257

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000350763	ENSP00000265131
ENST00000341037	ENSP00000339553
ENST00000423613	ENSP00000411406
ENST00000460345
ENST00000498724
ENST00000476680
ENST00000473855
ENST00000481475
ENST00000537320	ENSP00000443478
ENST00000542877	ENSP00000442242
ENST00000544972	ENSP00000445380
ENST00000534839	ENSP00000443469
ENST00000535648	ENSP00000438152

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045545	syndecan binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007528	neuromuscular junction development
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0010628	positive regulation of gene expression
GO:0014012	peripheral nervous system axon regeneration
GO:0030198	extracellular matrix organization
GO:0031175	neuron projection development
GO:0042060	wound healing
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045471	response to ethanol
GO:0060447	bud outgrowth involved in lung branching
GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development
GO:0060740	prostate gland epithelium morphogenesis
GO:0071300	cellular response to retinoic acid
GO:0071305	cellular response to vitamin D
GO:0071774	response to fibroblast growth factor
GO:0071799	cellular response to prostaglandin D stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005614	interstitial matrix
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix