InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBP1

Summary

InnateDB Protein

IDBP-82389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBP1

Protein Name

Z-DNA binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360215

InnateDB Gene

IDBG-82385 (ZBP1)

Protein Structure

UniProt Annotation

Function

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003692	left-handed Z-DNA binding
GO:0003723	RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0060340	positive regulation of type I interferon-mediated signaling pathway