Homo sapiens Gene: ZBP1
Summary
InnateDB Gene IDBG-82385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBP1
Gene Name Z-DNA binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124256
Encoded Proteins
Z-DNA binding protein 1
Z-DNA binding protein 1
Z-DNA binding protein 1
Z-DNA binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ZBP1 is a cytosolic DNA sensor that upon binding to DNA, associates with IRF3 transcription factor and TBK1 serine/threonine kinase, selectively enhancing DNA mediated induction of type-I-IFN.
ZBP1 is a cytosolic pattern recognition receptor of double-stranded DNA and is essential for IRF3 activation and interferon beta expression triggered by human cytomegalovirus (HCMV), as well as being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion.
ZBP1 (DAI) enhanced HIV-1 replication, which is largely impaired by mutations at kappaB sites in HIV-1 long terminal repeat (LTR) or by suppressing activation of NF-kappaB.
ZBP1 interacts with RIPK3 to mediate virus-induced necrosis. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Zbp1 interacts with Ripk3 to mediate virus-induced necrosis.
[Mus musculus] Ddx58 acts in parallel with Zbp1 in an RNA polymerase III-dependent manner to initiate glial responses to herpes simplex virus-1.
Entrez Gene
Summary This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:57603846-57620576
Strand Reverse strand
Band q13.31
Transcripts
ENST00000371173 ENSP00000360215
ENST00000395822 ENSP00000379167
ENST00000453793 ENSP00000404620
ENST00000432548
ENST00000461547
ENST00000480037
ENST00000541799 ENSP00000440552
ENST00000546110
ENST00000538947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003692 left-handed Z-DNA binding
GO:0003723 RNA binding
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response (InnateDB)
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
RIP-mediated NFkB activation via ZBP1 pathway
STING mediated induction of host immune responses pathway
IRF3-mediated induction of type I IFN pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
IRF3 mediated activation of type 1 IFN pathway
Innate Immune System pathway
Regulation of innate immune responses to cytosolic DNA pathway
Immune System pathway
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
Cytosolic DNA-sensing pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H171
TrEMBL
UniProt Splice Variant
Entrez Gene 81030
UniGene Hs.302123
RefSeq NM_001160418 NM_001160417 NM_030776 NM_001160419
HUGO HGNC:16176
OMIM 606750
CCDS CCDS54477 CCDS13461 CCDS54478
HPRD 09484
IMGT
EMBL AJ300575 AK122761 AL035541 BC028218 CH471077 CT002036
GenPept AAH28218 BAG53713 CAC18810 CAI23107 CAM28299 EAW75511
RNA Seq Atlas 81030