InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZBP1

Summary

InnateDB Gene

IDBG-82385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBP1

Gene Name

Z-DNA binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000124256

Encoded Proteins

IDBP-82389

Z-DNA binding protein 1

IDBP-238768

Z-DNA binding protein 1

IDBP-379303

Z-DNA binding protein 1

IDBP-586679

Z-DNA binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17618271

ZBP1 is a cytosolic DNA sensor that upon binding to DNA, associates with IRF3 transcription factor and TBK1 serine/threonine kinase, selectively enhancing DNA mediated induction of type-I-IFN.

PMID 19846511

ZBP1 is a cytosolic pattern recognition receptor of double-stranded DNA and is essential for IRF3 activation and interferon beta expression triggered by human cytomegalovirus (HCMV), as well as being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion.

PMID 20599623

ZBP1 (DAI) enhanced HIV-1 replication, which is largely impaired by mutations at kappaB sites in HIV-1 long terminal repeat (LTR) or by suppressing activation of NF-kappaB.

PMID 22423968

ZBP1 interacts with RIPK3 to mediate virus-induced necrosis. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22423968

[Mus musculus] Zbp1 interacts with Ripk3 to mediate virus-induced necrosis.

PMID 26146945

[Mus musculus] Ddx58 acts in parallel with Zbp1 in an RNA polymerase III-dependent manner to initiate glial responses to herpes simplex virus-1.

Entrez Gene

Summary

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:57603846-57620576

Strand

Reverse strand

Band

q13.31

Transcripts

ENST00000371173	ENSP00000360215
ENST00000395822	ENSP00000379167
ENST00000453793	ENSP00000404620
ENST00000432548
ENST00000461547
ENST00000480037
ENST00000541799	ENSP00000440552
ENST00000546110
ENST00000538947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003692	left-handed Z-DNA binding
GO:0003723	RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0060340	positive regulation of type I interferon-mediated signaling pathway