InnateDB Protein
|
IDBP-82460.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
IDE
|
Protein Name
|
insulin-degrading enzyme
|
Synonyms
|
INSULYSIN;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000360637
|
InnateDB Gene
|
IDBG-82456 (IDE)
|
Protein Structure
|
|
Function |
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269PubMed:10684867, ECO:0000269PubMed:17613531, ECO:0000269PubMed:18986166}.
|
Subcellular Localization |
Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
38
[view]
|
Protein-Protein |
38
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007863
Peptidase M16, C-terminal domain
IPR011249
Metalloenzyme, LuxS/M16 peptidase-like
|
PFAM |
PF05193
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P14735
|
PhosphoSite |
PhosphoSite-P14735
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
3416
|
UniGene |
Hs.500546
|
RefSeq |
NP_001159418
|
HUGO |
HGNC:5381
|
OMIM |
146680
|
CCDS |
CCDS53554
|
HPRD |
00894
|
IMGT |
|
EMBL |
AK312810
AK316407
AL356128
BC096336
BC096337
BC096339
CH471066
M21188
|
GenPept |
AAA52712
AAH96336
AAH96337
AAH96339
BAG35668
BAH14778
CAI13670
EAW50090
EAW50091
|
|
|