InnateDB Protein
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IDBP-8274.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FUT6
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Protein Name
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fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
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Synonyms
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FCT3A; FT1A; Fuc-TVI; FucT-VI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000313398
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InnateDB Gene
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IDBG-20780 (FUT6)
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Protein Structure
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Function |
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
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Disease Associations |
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Tissue Specificity |
Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008417
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fucosyltransferase activity
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GO:0017060
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3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
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GO:0046920
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alpha-(1->3)-fucosyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001503
Glycosyl transferase, family 10
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PFAM |
PF00852
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P51993
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PhosphoSite |
PhosphoSite-P51993
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TrEMBL |
E9PS22
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UniProt Splice Variant |
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Entrez Gene |
2528
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UniGene |
Hs.705615
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RefSeq |
NP_000141
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HUGO |
HGNC:4017
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OMIM |
136836
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CCDS |
CCDS12152
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HPRD |
00651
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IMGT |
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EMBL |
AC024592
AF131211
AL031258
CH471139
L01698
M98825
U27331
U27332
U27333
U27334
U27335
U27336
U27337
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GenPept |
AAA99222
AAB03078
AAC50190
AAC50191
AAC50192
AAC50193
AAC50194
AAC50195
AAC50196
AAD33509
EAW69136
EAW69137
EAW69138
EAW69139
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