InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SP110

Summary

InnateDB Protein

IDBP-82820.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP110

Protein Name

SP110 nuclear body protein

Synonyms

IFI41; IFI75; IPR1; VODI;

Species

Homo sapiens

Ensembl Protein

ENSP00000258381

InnateDB Gene

IDBG-82818 (SP110)

Protein Structure

UniProt Annotation

Function

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00185, ECO:0000255PROSITE-ProRule:PRU00747, ECO:0000269PubMed:10913195}. Note=Found in the nuclear body.

Disease Associations

Hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]: Autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. {ECO:0000269PubMed:16648851}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0016032	viral process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR000770 SAND domain
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR004865 Sp100
IPR010919 SAND domain-like
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF01342
PF00439
PF03172
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00258
SM00297
SM00249

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt