Version 5.4
Homo sapiens Gene: SP110
Summary
InnateDB Gene IDBG-82818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SP110
Gene Name SP110 nuclear body protein
Synonyms IFI41; IFI75; IPR1; VODI
Species Homo sapiens
Ensembl Gene ENSG00000135899
Encoded Proteins
IDBP-82820
SP110 nuclear body protein
IDBP-82822
SP110 nuclear body protein
IDBP-82824
SP110 nuclear body protein
IDBP-246450
SP110 nuclear body protein
IDBP-292943
SP110 nuclear body protein
IDBP-389211
SP110 nuclear body protein
IDBP-389212
SP110 nuclear body protein
IDBP-593869
SP110 nuclear body protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:230167293-230225729
Strand Reverse strand
Band q37.1
Transcripts
ENST00000258381 ENSP00000258381
ENST00000358662 ENSP00000351488
ENST00000258382 ENSP00000258382
ENST00000392048 ENSP00000375902
ENST00000409815 ENSP00000387172
ENST00000455674 ENSP00000393992
ENST00000416610 ENSP00000399978
ENST00000477068
ENST00000480916
ENST00000483067
ENST00000463022
ENST00000489597
ENST00000490880
ENST00000486146
ENST00000462232
ENST00000540870 ENSP00000439558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 20 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000070034
View Gene Order
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.145150 Hs.574783 Hs.601987
RefSeq NM_001185015 NM_004509 NM_004510 NM_080424 XM_005246525 XM_005246527 XM_006712486 XM_006712487
HUGO
OMIM
CCDS CCDS2474 CCDS2475 CCDS2476 CCDS54435
HPRD 06832
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca