InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAK1

Summary

InnateDB Protein

IDBP-82950.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAK1

Protein Name

BCL2-antagonist/killer 1

Synonyms

BAK; BAK-LIKE; BCL2L7; CDN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000353878

InnateDB Gene

IDBG-82944 (BAK1)

Protein Structure

UniProt Annotation

Function

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. {ECO:0000269PubMed:17157251, ECO:0000269PubMed:8521816}.

Subcellular Localization

Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0034644	cellular response to UV
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0045862	positive regulation of proteolysis
GO:0046902	regulation of mitochondrial membrane permeability
GO:0051881	regulation of mitochondrial membrane potential
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097202	activation of cysteine-type endopeptidase activity
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway