Version 5.4
Homo sapiens Gene: BAK1
Summary
InnateDB Gene IDBG-82944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAK1
Gene Name BCL2-antagonist/killer 1
Synonyms BAK; BAK-LIKE; BCL2L7; CDN1
Species Homo sapiens
Ensembl Gene ENSG00000030110
Encoded Proteins
IDBP-82946
BCL2-antagonist/killer 1
IDBP-82950
BCL2-antagonist/killer 1
IDBP-375882
BCL2-antagonist/killer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33572547-33580293
Strand Reverse strand
Band p21.31
Transcripts
ENST00000374467 ENSP00000363591
ENST00000360661 ENSP00000353878
ENST00000442998 ENSP00000391258
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031072 heat shock protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051087 chaperone binding
GO:0051400 BH domain binding
Biological Process
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001836 release of cytochrome c from mitochondria
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420 brain development
GO:0007568 aging
GO:0008053 mitochondrial fusion
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620 response to fungus
GO:0010046 response to mycotoxin
GO:0010225 response to UV-C
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010629 negative regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0031018 endocrine pancreas development
GO:0031100 organ regeneration
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034644 cellular response to UV
GO:0035108 limb morphogenesis
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0044346 fibroblast apoptotic process
GO:0045471 response to ethanol
GO:0045862 positive regulation of proteolysis
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048872 homeostasis of number of cells
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0060068 vagina development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 thymocyte apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262 apoptotic process involved in patterning of blood vessels
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0031966 mitochondrial membrane
GO:0046930 pore complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057789
View Gene Order
ENSBTAG00000000428
Not yet available
Pathways
NETPATH
REACTOME
REACT_707
Activation and oligomerization of BAK protein pathway
REACT_578
Apoptosis pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001188
HUGO
OMIM
CCDS CCDS4781
HPRD 02744
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca