InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL13RA2

Summary

InnateDB Protein

IDBP-82960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL13RA2

Protein Name

interleukin 13 receptor, alpha 2

Synonyms

CD213A2; CT19; IL-13R; IL13BP;

Species

Homo sapiens

Ensembl Protein

ENSP00000361004

InnateDB Gene

IDBG-82958 (IL13RA2)

Protein Structure

UniProt Annotation

Function

Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). {ECO:0000269PubMed:20223216}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003961 Fibronectin, type III
IPR015321 Interleukin-6 receptor alpha, binding

PFAM

PF00041
PF01108
PF09240

PRINTS

PIRSF

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14627

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

3598

UniGene

RefSeq

HUGO

HGNC:5975

OMIM

300130

CCDS

CCDS14565

HPRD

02132

IMGT

EMBL

AK291957 AL121878 AY656702 BC020739 BC033705 U70981 X95302 Y08768

GenPept

AAB17170 AAH20739 AAH33705 AAT49099 BAF84646 CAA64617 CAA70021 CAD18962