InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITPR3

Summary

InnateDB Protein

IDBP-82974.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPR3

Protein Name

inositol 1,4,5-trisphosphate receptor, type 3

Synonyms

IP3R; IP3R3;

Species

Homo sapiens

Ensembl Protein

ENSP00000363435

InnateDB Gene

IDBG-82972 (ITPR3)

Protein Structure

UniProt Annotation

Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in intestinal crypt and villus epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000822	inositol hexakisphosphate binding
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0007613	memory
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030168	platelet activation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0050913	sensory perception of bitter taste
GO:0050916	sensory perception of sweet taste
GO:0050917	sensory perception of umami taste
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0060291	long-term synaptic potentiation
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005640	nuclear outer membrane
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0031095	platelet dense tubular network membrane
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0043235	receptor complex
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016024 Armadillo-type fold
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt