InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITPR3

Summary

InnateDB Gene

IDBG-82972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPR3

Gene Name

inositol 1,4,5-trisphosphate receptor, type 3

Synonyms

IP3R; IP3R3

Species

Homo sapiens

Ensembl Gene

ENSG00000096433

Encoded Proteins

IDBP-82974

inositol 1,4,5-trisphosphate receptor, type 3

IDBP-806520

inositol 1,4,5-trisphosphate receptor, type 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21239714

ITPR3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.

InnateDB Annotation from Orthologs

Summary

PMID 21239714

[Mus musculus] Itpr3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.

Entrez Gene

Summary

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:33620365-33696574

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000374316	ENSP00000363435
ENST00000605930	ENSP00000475177

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000822	inositol hexakisphosphate binding
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0007613	memory
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030168	platelet activation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0050913	sensory perception of bitter taste
GO:0050916	sensory perception of sweet taste
GO:0050917	sensory perception of umami taste
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0060291	long-term synaptic potentiation
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005640	nuclear outer membrane
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0031095	platelet dense tubular network membrane
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0043235	receptor complex
GO:0045177	apical part of cell

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042644

View Gene Order

ENSBTAG00000013245

Not yet available

Pathways

NETPATH

REACTOME

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_160158

Role of phospholipids in phagocytosis pathway

REACT_118700

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway

REACT_162

Elevation of cytosolic Ca2+ levels pathway

REACT_23876

Platelet homeostasis pathway

REACT_2202

Effects of PIP2 hydrolysis pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_18274

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1505

Integration of energy metabolism pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_23905

Platelet calcium homeostasis pathway

REACT_12529

Signaling by VEGF pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_15526

G-protein mediated events pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_228024

VEGFR2 mediated cell proliferation pathway

REACT_228166

VEGFA-VEGFR2 Pathway pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_111217

Metabolism pathway

REACT_163834

FCERI mediated Ca+2 mobilization pathway

REACT_118773

Signaling by the B Cell Receptor (BCR) pathway

REACT_116125

Disease pathway

REACT_604

Hemostasis pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04540

Gap junction pathway

hsa04720

Long-term potentiation pathway

hsa05010

Alzheimer's disease pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa04742

Taste transduction pathway

hsa04730

Long-term depression pathway

hsa04020

Calcium signaling pathway pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04114

Oocyte meiosis pathway

hsa04971

Gastric acid secretion pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

INOH website

B cell receptor signaling pathway

INOH website

VEGF signaling pathway pathway

INOH website

GPCR GroupI metabotropic glutamate receptor signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

Q14573

TrEMBL

A6H8K3

UniProt Splice Variant

Entrez Gene

3710

UniGene

RefSeq

NM_002224

HUGO

HGNC:6182

OMIM

147267

CCDS

CCDS4783

HPRD

IMGT

EMBL

AL139044 BC146646 CH471081 D26351 U01062

GenPept

AAC50064 AAI46647 BAA05385 CAI16455 EAX03744

RNA Seq Atlas

3710