Homo sapiens Gene: ITPR3
InnateDB Gene IDBG-82972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPR3
Gene Name inositol 1,4,5-trisphosphate receptor, type 3
Synonyms IP3R; IP3R3
Species Homo sapiens
Ensembl Gene ENSG00000096433
Encoded Proteins
inositol 1,4,5-trisphosphate receptor, type 3
inositol 1,4,5-trisphosphate receptor, type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
ITPR3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.
InnateDB Annotation from Orthologs
[Mus musculus] Itpr3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.
Entrez Gene
Summary This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33620365-33696574
Strand Forward strand
Band p21.31
ENST00000374316 ENSP00000363435
ENST00000605930 ENSP00000475177
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000822 inositol hexakisphosphate binding
GO:0005216 ion channel activity
GO:0005218 intracellular ligand-gated calcium channel activity
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0007613 memory
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030168 platelet activation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050796 regulation of insulin secretion
GO:0050913 sensory perception of bitter taste
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0060291 long-term synaptic potentiation
GO:0060402 calcium ion transport into cytosol
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0031095 platelet dense tubular network membrane
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0043235 receptor complex
GO:0045177 apical part of cell
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Elevation of cytosolic Ca2+ levels pathway
Platelet homeostasis pathway
Effects of PIP2 hydrolysis pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Platelet calcium homeostasis pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Adaptive Immune System pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Metabolism pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
GnRH signaling pathway pathway
Gap junction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Phosphatidylinositol signaling system pathway
Taste transduction pathway
Long-term depression pathway
Calcium signaling pathway pathway
Vascular smooth muscle contraction pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Salivary secretion pathway
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
SwissProt Q14573
UniProt Splice Variant
Entrez Gene 3710
RefSeq NM_002224
OMIM 147267
EMBL AL139044 BC146646 CH471081 D26351 U01062
GenPept AAC50064 AAI46647 BAA05385 CAI16455 EAX03744
RNA Seq Atlas 3710