InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SORBS1

Summary

InnateDB Protein

IDBP-83392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SORBS1

Protein Name

sorbin and SH3 domain containing 1

Synonyms

CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000360271

InnateDB Gene

IDBG-83362 (SORBS1)

Protein Structure

UniProt Annotation

Function

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250UniProtKB:Q62417}.

Subcellular Localization

Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. {ECO:0000269PubMed:11374898, ECO:0000269PubMed:17462669}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0006936	muscle contraction
GO:0007160	cell-matrix adhesion
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0015758	glucose transport
GO:0032869	cellular response to insulin stimulus
GO:0043149	stress fiber assembly
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0046889	positive regulation of lipid biosynthetic process
GO:0048041	focal adhesion assembly
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005899	insulin receptor complex
GO:0005913	cell-cell adherens junction
GO:0005915	zonula adherens
GO:0005924	cell-substrate adherens junction
GO:0005925	focal adhesion
GO:0016363	nuclear matrix
GO:0045121	membrane raft