Version 5.4
Homo sapiens Gene: SORBS1
Summary
InnateDB Gene IDBG-83362.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORBS1
Gene Name sorbin and SH3 domain containing 1
Synonyms CAP; FLAF2; R85FL; SH3D5; SH3P12; SORB1;
Species Homo sapiens
Ensembl Gene ENSG00000095637
Encoded Proteins
IDBP-83364
sorbin and SH3 domain containing 1
IDBP-83366
sorbin and SH3 domain containing 1
IDBP-83368
sorbin and SH3 domain containing 1
IDBP-83370
sorbin and SH3 domain containing 1
IDBP-83372
sorbin and SH3 domain containing 1
IDBP-83376
sorbin and SH3 domain containing 1
IDBP-83378
sorbin and SH3 domain containing 1
IDBP-83380
sorbin and SH3 domain containing 1
IDBP-83382
sorbin and SH3 domain containing 1
IDBP-83388
sorbin and SH3 domain containing 1
IDBP-83392
sorbin and SH3 domain containing 1
IDBP-813251
sorbin and SH3 domain containing 1
IDBP-813252
sorbin and SH3 domain containing 1
IDBP-813249
sorbin and SH3 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:95311771-95561414
Strand Reverse strand
Band q24.1
Transcripts
ENST00000306402 ENSP00000302556
ENST00000371249 ENSP00000360295
ENST00000371247 ENSP00000360293
ENST00000371246 ENSP00000360292
ENST00000371245 ENSP00000360291
ENST00000354106 ENSP00000277984
ENST00000371239 ENSP00000360283
ENST00000371241 ENSP00000360285
ENST00000277982 ENSP00000277982
ENST00000361941 ENSP00000355136
ENST00000371227 ENSP00000360271
ENST00000472854
ENST00000486141 ENSP00000473813
ENST00000465489
ENST00000492542 ENSP00000474932
ENST00000474353
ENST00000482068
ENST00000607232 ENSP00000475901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006936 muscle contraction
GO:0007160 cell-matrix adhesion
GO:0008286 insulin receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0015758 glucose transport
GO:0032869 cellular response to insulin stimulus
GO:0043149 stress fiber assembly
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048041 focal adhesion assembly
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005899 insulin receptor complex
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0016363 nuclear matrix
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000025006
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000002880
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa04520
Adherens junction pathway
hsa04910
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
insulin_pathway
Insulin Pathway
Cross-References
SwissProt Q9BX66
TrEMBL
UniProt Splice Variant
Entrez Gene 10580
UniGene Hs.38621 Hs.721201 Hs.741504
RefSeq NM_001290294 XM_005269427 NM_001034957 NM_024991 NM_001290295 NM_015385 NM_001034954 NM_001034955 NM_001034956 NM_006434 XM_006717593 XM_006717595 XM_006717581 XM_006717574
HUGO HGNC:14565
OMIM 605264
CCDS CCDS73169 CCDS31253 CCDS7442 CCDS31255 CCDS31254 CCDS31256 CCDS31252
HPRD 05587
IMGT
EMBL AB037717 AF136380 AF136381 AF330623 AF330624 AF356525 AF356526 AF356527 AJ489942 AL117472 AL158165 AM260536 BC042612 BC152463 CH471066 U70668
GenPept AAB93496 AAD27647 AAF22175 AAH42612 AAI52464 AAK37563 AAK37564 AAK37565 AAK57479 AAK57480 BAA92534 CAB55947 CAD34588 CAI14378 CAI14379 CAI14380 CAI14381 CAI14382 CAI14383 CAI14384 CAI14385 CAJ97431 EAW49999 EAW50007
RNA Seq Atlas 10580

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca