InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARD

Summary

InnateDB Protein

IDBP-83944.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARD

Protein Name

peroxisome proliferator-activated receptor delta

Synonyms

FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB;

Species

Homo sapiens

Ensembl Protein

ENSP00000337063

InnateDB Gene

IDBG-83938 (PPARD)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. {ECO:0000269PubMed:1333051, ECO:0000269PubMed:15604518}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous with maximal levels in placenta and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	47 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0043565	sequence-specific DNA binding
GO:0070539	linoleic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006006	glucose metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0007566	embryo implantation
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0008366	axon ensheathment
GO:0009062	fatty acid catabolic process
GO:0010467	gene expression
GO:0015758	glucose transport
GO:0015908	fatty acid transport
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045600	positive regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046697	decidualization
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003075 Peroxisome proliferator-activated receptor, beta
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01288
PR01290

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt