Homo sapiens Gene: PPARD
Summary
InnateDB Gene IDBG-83938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPARD
Gene Name peroxisome proliferator-activated receptor delta
Synonyms FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB;
Species Homo sapiens
Ensembl Gene ENSG00000112033
Encoded Proteins
peroxisome proliferator-activated receptor delta
peroxisome proliferator-activated receptor delta
peroxisome proliferator-activated receptor delta
peroxisome proliferator-activated receptor delta
peroxisome proliferator-activated receptor delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:35342558-35428191
Strand Forward strand
Band p21.31
Transcripts
ENST00000360694 ENSP00000353916
ENST00000311565 ENSP00000310928
ENST00000337400 ENSP00000337063
ENST00000448077 ENSP00000414372
ENST00000418635 ENSP00000413314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 47 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0043565 sequence-specific DNA binding
GO:0051059 NF-kappaB binding
GO:0070539 linoleic acid binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0006006 glucose metabolic process
GO:0006029 proteoglycan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006776 vitamin A metabolic process
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0008203 cholesterol metabolic process
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008366 axon ensheathment
GO:0008654 phospholipid biosynthetic process
GO:0009062 fatty acid catabolic process
GO:0009299 mRNA transcription
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015758 glucose transport
GO:0015908 fatty acid transport
GO:0019395 fatty acid oxidation
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030522 intracellular receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0032024 positive regulation of insulin secretion
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0042640 anagen
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043616 keratinocyte proliferation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045684 positive regulation of epidermis development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045909 positive regulation of vasodilation
GO:0046697 decidualization
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051546 keratinocyte migration
GO:0060612 adipose tissue development
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
Nuclear Receptor transcription pathway pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Generic Transcription Pathway pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Regulation of pyruvate dehydrogenase (PDH) complex pathway
Gene Expression pathway
KEGG
PPAR signaling pathway pathway
Wnt signaling pathway pathway
Pathways in cancer pathway
Acute myeloid leukemia pathway
INOH
PID BIOCARTA
Wnt signaling pathway [Biocarta view]
Basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q03181
TrEMBL A0A024RCW6 F5H830
UniProt Splice Variant
Entrez Gene 5467
UniGene Hs.696032
RefSeq NM_006238 XM_005249193 XM_006715120 XM_006715121 XM_006715123 NM_177435 NM_001171818 NM_001171820 NM_001171819 XM_006715122
HUGO HGNC:9235
OMIM 600409
CCDS CCDS4803 CCDS4804 CCDS54995 CCDS54994
HPRD 02679
IMGT
EMBL AB099507 AB307691 AF246299 AF246300 AF246301 AF246302 AF246303 AK122614 AK291661 AK296425 AK304878 AL022721 AY442342 AY919140 BC002715 BC007578 CH471081 L07592
GenPept AAA36469 AAF62553 AAH02715 AAH07578 AAR05439 AAX14041 BAC78903 BAF84350 BAG53624 BAG65615 BAH02282 BAH12347 CAB38629 CAD92505 EAX03825 EAX03827 EAX03828
RNA Seq Atlas 5467