InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF4

Summary

InnateDB Protein

IDBP-84607.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF4

Protein Name

tumor necrosis factor receptor superfamily, member 4

Synonyms

ACT35; CD134; IMD16; OX40; TXGP1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000368538

InnateDB Gene

IDBG-84605 (TNFRSF4)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269PubMed:7704935}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Immunodeficiency 16 (IMD16) [MIM:615593]: An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. {ECO:0000269PubMed:23897980}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0030890	positive regulation of B cell proliferation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042098	T cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045859	regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050710	negative regulation of cytokine secretion
GO:0051024	positive regulation of immunoglobulin secretion