InnateDB Protein
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IDBP-84775.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CAPN10
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Protein Name
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calpain 10
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Synonyms
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CANP10; NIDDM1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000270364
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InnateDB Gene
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IDBG-84773 (CAPN10)
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Protein Structure
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Function |
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269PubMed:17572128}.
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Subcellular Localization |
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Disease Associations |
Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:11017071, ECO:0000269PubMed:16721485}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Detected in primary skeletal muscle cells (at protein level). Ubiquitous. {ECO:0000269PubMed:17572128}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006508
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proteolysis
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GO:0006921
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cellular component disassembly involved in execution phase of apoptosis
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GO:0031532
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actin cytoskeleton reorganization
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GO:0032024
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positive regulation of insulin secretion
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GO:0032388
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positive regulation of intracellular transport
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GO:0032869
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cellular response to insulin stimulus
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GO:0046326
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positive regulation of glucose import
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GO:0097050
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type B pancreatic cell apoptotic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001300
Peptidase C2, calpain, catalytic domain
IPR022684
Peptidase C2, calpain family
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PFAM |
PF00648
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PRINTS |
PR00704
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PIRSF |
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SMART |
SM00230
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HC96
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PhosphoSite |
PhosphoSite-Q9HC96
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11132
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UniGene |
Hs.728234
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RefSeq |
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HUGO |
HGNC:1477
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OMIM |
605286
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CCDS |
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HPRD |
05595
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IMGT |
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EMBL |
AB058748
AC124862
AF089088
AF089090
AF089091
AF089092
AF089093
AF089094
AF089095
AF089096
AK074807
BC004260
BC007553
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GenPept |
AAG17966
AAG17968
AAG17969
AAG17970
AAG17971
AAG17972
AAG17973
AAG17974
AAH04260
AAH07553
AAX88944
BAB47474
BAC11220
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