InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPN10

Summary

InnateDB Protein

IDBP-84775.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN10

Protein Name

calpain 10

Synonyms

CANP10; NIDDM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000270364

InnateDB Gene

IDBG-84773 (CAPN10)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269PubMed:17572128}.

Subcellular Localization

Disease Associations

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:11017071, ECO:0000269PubMed:16721485}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Detected in primary skeletal muscle cells (at protein level). Ubiquitous. {ECO:0000269PubMed:17572128}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0006508	proteolysis
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0031532	actin cytoskeleton reorganization
GO:0032024	positive regulation of insulin secretion
GO:0032388	positive regulation of intracellular transport
GO:0032869	cellular response to insulin stimulus
GO:0046326	positive regulation of glucose import
GO:0097050	type B pancreatic cell apoptotic process