Homo sapiens Gene: CAPN10
Summary
InnateDB Gene IDBG-84773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN10
Gene Name calpain 10
Synonyms CANP10; NIDDM1;
Species Homo sapiens
Ensembl Gene ENSG00000142330
Encoded Proteins
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
calpain 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:240586716-240617705
Strand Forward strand
Band q37.3
Transcripts
ENST00000270364 ENSP00000270364
ENST00000270361 ENSP00000270361
ENST00000357048 ENSP00000349556
ENST00000354082 ENSP00000270362
ENST00000352879 ENSP00000289381
ENST00000391984 ENSP00000375844
ENST00000391983 ENSP00000375843
ENST00000404753 ENSP00000384422
ENST00000416591 ENSP00000400144
ENST00000432084 ENSP00000407090
ENST00000426297 ENSP00000404064
ENST00000463653
ENST00000494738
ENST00000465943
ENST00000483602
ENST00000493058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0006508 proteolysis
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0031532 actin cytoskeleton reorganization
GO:0032024 positive regulation of insulin secretion
GO:0032388 positive regulation of intracellular transport
GO:0032869 cellular response to insulin stimulus
GO:0046326 positive regulation of glucose import
GO:0097050 type B pancreatic cell apoptotic process
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005623 cell
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.728234
RefSeq NM_023083 NM_023085
HUGO
OMIM
CCDS CCDS33420 CCDS42838
HPRD 05595
IMGT
EMBL
GenPept
RNA Seq Atlas