InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAPN10

Summary

InnateDB Gene

IDBG-84773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN10

Gene Name

calpain 10

Synonyms

CANP10; NIDDM1

Species

Homo sapiens

Ensembl Gene

ENSG00000142330

Encoded Proteins

IDBP-84775

calpain 10

IDBP-84777

calpain 10

IDBP-84779

calpain 10

IDBP-84783

calpain 10

IDBP-84785

calpain 10

IDBP-246586

calpain 10

IDBP-246588

calpain 10

IDBP-292829

calpain 10

IDBP-389586

calpain 10

IDBP-389587

calpain 10

IDBP-389588

calpain 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:240586716-240617705

Strand

Forward strand

Band

q37.3

Transcripts

ENST00000270364	ENSP00000270364
ENST00000270361	ENSP00000270361
ENST00000357048	ENSP00000349556
ENST00000354082	ENSP00000270362
ENST00000352879	ENSP00000289381
ENST00000391984	ENSP00000375844
ENST00000391983	ENSP00000375843
ENST00000404753	ENSP00000384422
ENST00000416591	ENSP00000400144
ENST00000432084	ENSP00000407090
ENST00000426297	ENSP00000404064
ENST00000463653
ENST00000494738
ENST00000465943
ENST00000483602
ENST00000493058

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0006508	proteolysis
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0031532	actin cytoskeleton reorganization
GO:0032024	positive regulation of insulin secretion
GO:0032388	positive regulation of intracellular transport
GO:0032869	cellular response to insulin stimulus
GO:0046326	positive regulation of glucose import
GO:0097050	type B pancreatic cell apoptotic process
GO:2000676	positive regulation of type B pancreatic cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005623	cell
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026270

View Gene Order

ENSBTAG00000002809

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

11132

UniGene

Hs.728234

RefSeq

NM_023083 NM_023085

HUGO

HGNC:1477

OMIM

605286

CCDS

CCDS33420 CCDS42838

HPRD

05595

IMGT

EMBL

GenPept

RNA Seq Atlas

11132