InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPN10

Summary

InnateDB Protein

IDBP-84779.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN10

Protein Name

calpain 10

Synonyms

CANP10; NIDDM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349556

InnateDB Gene

IDBG-84773 (CAPN10)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269PubMed:17572128}.

Subcellular Localization

Disease Associations

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:11017071, ECO:0000269PubMed:16721485}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Detected in primary skeletal muscle cells (at protein level). Ubiquitous. {ECO:0000269PubMed:17572128}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0006508	proteolysis
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0031532	actin cytoskeleton reorganization
GO:0032024	positive regulation of insulin secretion
GO:0032388	positive regulation of intracellular transport
GO:0032869	cellular response to insulin stimulus
GO:0046326	positive regulation of glucose import
GO:0097050	type B pancreatic cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005623	cell
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001300 Peptidase C2, calpain, catalytic domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00648
PF01067

PRINTS

PR00704

PIRSF

SMART

SM00230
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt