InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STK25

Summary

InnateDB Protein

IDBP-85166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK25

Protein Name

serine/threonine kinase 25

Synonyms

SOK1; YSK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000325748

InnateDB Gene

IDBG-85164 (STK25)

Protein Structure

UniProt Annotation

Function

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. {ECO:0000269PubMed:15037601}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15037601}. Golgi apparatus {ECO:0000269PubMed:15037601}. Note=Localizes to the Golgi apparatus.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006979	response to oxidative stress
GO:0007163	establishment or maintenance of cell polarity
GO:0007165	signal transduction
GO:0023014	signal transduction by phosphorylation
GO:0050772	positive regulation of axonogenesis
GO:0051645	Golgi localization

Cellular Component

GO:0005794

Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt