Version 5.4
Homo sapiens Gene: STK25
Summary
InnateDB Gene IDBG-85164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK25
Gene Name serine/threonine kinase 25
Synonyms SOK1; YSK1
Species Homo sapiens
Ensembl Gene ENSG00000115694
Encoded Proteins
IDBP-85166
serine/threonine kinase 25
IDBP-295590
serine/threonine kinase 25
IDBP-292404
serine/threonine kinase 25
IDBP-295662
serine/threonine kinase 25
IDBP-295547
serine/threonine kinase 25
IDBP-389699
serine/threonine kinase 25
IDBP-389700
serine/threonine kinase 25
IDBP-389701
serine/threonine kinase 25
IDBP-389702
serine/threonine kinase 25
IDBP-389703
serine/threonine kinase 25
IDBP-389704
serine/threonine kinase 25
IDBP-389705
serine/threonine kinase 25
IDBP-389706
serine/threonine kinase 25
IDBP-389707
serine/threonine kinase 25
IDBP-389708
serine/threonine kinase 25
IDBP-389711
serine/threonine kinase 25
IDBP-389712
serine/threonine kinase 25
IDBP-584049
serine/threonine kinase 25
IDBP-590222
serine/threonine kinase 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241492674-241509730
Strand Reverse strand
Band q37.3
Transcripts
ENST00000316586 ENSP00000325748
ENST00000403346 ENSP00000384162
ENST00000401869 ENSP00000385687
ENST00000405883 ENSP00000384444
ENST00000405585 ENSP00000385541
ENST00000423004 ENSP00000404469
ENST00000450497 ENSP00000399212
ENST00000442307 ENSP00000403607
ENST00000424537 ENSP00000417020
ENST00000413760 ENSP00000395104
ENST00000429279 ENSP00000404960
ENST00000436402 ENSP00000412617
ENST00000440109 ENSP00000403866
ENST00000435225 ENSP00000401114
ENST00000439101 ENSP00000406208
ENST00000452891
ENST00000436917
ENST00000426941 ENSP00000414191
ENST00000420551 ENSP00000404552
ENST00000472181
ENST00000494699
ENST00000487962
ENST00000478403
ENST00000470438
ENST00000465009
ENST00000462953
ENST00000495143
ENST00000461760
ENST00000492127
ENST00000479442
ENST00000496159
ENST00000483603
ENST00000495372
ENST00000543554 ENSP00000444886
ENST00000535007 ENSP00000446008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0023014 signal transduction by phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0051645 Golgi localization
Cellular Component
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026277
View Gene Order
ENSBTAG00000009676
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.739974
RefSeq NM_001271977 NM_001271978 NM_001271979 NM_001271980 NM_001282305 NM_001282306 NM_001282307 NM_001282308 NM_006374
HUGO
OMIM
CCDS CCDS2549 CCDS63199 CCDS63200
HPRD 03770
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca