InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAG2

Summary

InnateDB Protein

IDBP-85184.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAG2

Protein Name

stromal antigen 2

Synonyms

bA517O1.1; SA-2; SA2; SCC3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000360187

InnateDB Gene

IDBG-85176 (STAG2)

Protein Structure

UniProt Annotation

Function

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269PubMed:12034751}.

Subcellular Localization

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007062	sister chromatid cohesion
GO:0007067	mitotic nuclear division
GO:0007126	meiotic nuclear division
GO:0032876	negative regulation of DNA endoreduplication

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0045111	intermediate filament cytoskeleton