Version 5.4
Homo sapiens Gene: STAG2
Summary
InnateDB Gene IDBG-85176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAG2
Gene Name stromal antigen 2
Synonyms bA517O1.1; SA-2; SA2; SCC3B
Species Homo sapiens
Ensembl Gene ENSG00000101972
Encoded Proteins
IDBP-85180
stromal antigen 2
IDBP-85182
stromal antigen 2
IDBP-85184
stromal antigen 2
IDBP-85186
stromal antigen 2
IDBP-85188
stromal antigen 2
IDBP-241434
stromal antigen 2
IDBP-241436
stromal antigen 2
IDBP-380442
stromal antigen 2
IDBP-380477
stromal antigen 2
IDBP-380483
stromal antigen 2
IDBP-380487
stromal antigen 2
IDBP-380488
stromal antigen 2
IDBP-380489
stromal antigen 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:123960212-124422664
Strand Forward strand
Band q25
Transcripts
ENST00000371160 ENSP00000360202
ENST00000371157 ENSP00000360199
ENST00000371145 ENSP00000360187
ENST00000371144 ENSP00000360186
ENST00000218089 ENSP00000218089
ENST00000394478 ENSP00000377988
ENST00000394477 ENSP00000377987
ENST00000455404 ENSP00000397265
ENST00000458700 ENSP00000405555
ENST00000435103 ENSP00000405874
ENST00000458176 ENSP00000401309
ENST00000428941 ENSP00000415103
ENST00000435215 ENSP00000392118
ENST00000483575
ENST00000469481
ENST00000466748
ENST00000471107
ENST00000475602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007062 sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0019827 stem cell maintenance
GO:0032876 negative regulation of DNA endoreduplication
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025862
View Gene Order
ENSBTAG00000009121
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_150421
Cohesin Loading onto Chromatin pathway
REACT_1932
Mitotic Telophase/Cytokinesis pathway
REACT_150266
Establishment of Sister Chromatid Cohesion pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_111183
Meiosis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496710 Hs.624663
RefSeq NM_001042749 NM_001042750 NM_001042751 NM_001282418 NM_006603 XM_005262357 XM_005262358 XM_005262359 XM_005262360 XM_005262361 XM_006724727
HUGO
OMIM
CCDS CCDS14607 CCDS43990
HPRD 05077
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca