InnateDB Protein
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IDBP-85188.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STAG2
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Protein Name
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stromal antigen 2
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Synonyms
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bA517O1.1; SA-2; SA2; SCC3B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000218089
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InnateDB Gene
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IDBG-85176 (STAG2)
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Protein Structure
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Function |
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269PubMed:12034751}.
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Subcellular Localization |
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
45
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013721
STAG
IPR016024
Armadillo-type fold
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PFAM |
PF08514
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N3U4
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PhosphoSite |
PhosphoSite-Q8N3U4
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TrEMBL |
B1AMT4
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UniProt Splice Variant |
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Entrez Gene |
10735
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UniGene |
Hs.624663
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RefSeq |
NP_001036214
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HUGO |
HGNC:11355
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OMIM |
300826
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CCDS |
CCDS43990
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HPRD |
05077
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IMGT |
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EMBL |
AL022718
AL121601
AL355476
AL391241
AL512268
AL831939
BC001765
CH471107
CR749433
Z75331
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GenPept |
AAH01765
CAA99732
CAD38591
CAH18271
CAI40990
CAI40991
EAX11853
EAX11854
EAX11855
EAX11856
EAX11857
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