Version 5.4
Homo sapiens Protein: ENOX2
Summary
InnateDB Protein IDBP-86242.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENOX2
Protein Name ecto-NOX disulfide-thiol exchanger 2
Synonyms APK1; COVA1; tNOX;
Species Homo sapiens
Ensembl Protein ENSP00000359973
InnateDB Gene IDBG-86240 (ENOX2)
Protein Structure
UniProt Annotation
Function May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269PubMed:12356293, ECO:0000269PubMed:9932650}.
Subcellular Localization Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
Disease Associations
Tissue Specificity Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0007624 ultradian rhythm
GO:0016049 cell growth
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16206
PhosphoSite PhosphoSite-Q16206
TrEMBL B1AKF7
UniProt Splice Variant
Entrez Gene 10495
UniGene Hs.171458
RefSeq NP_001268665
HUGO HGNC:2259
OMIM 300282
CCDS CCDS14627
HPRD 02234
IMGT
EMBL AF207881 AK000353 AK289812 AK289837 AL022153 AL049565 AL049733 AL133207 AL591908 BC019254 BC140874 CH471107 S72904 Z80232
GenPept AAB30428 AAF20934 AAH19254 AAI40875 BAF82501 BAF82526 CAB61581 CAH71675 CAH71676 CAI43113 CAI43114 EAX11796 EAX11797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca