Homo sapiens Gene: ENOX2
Summary
InnateDB Gene IDBG-86240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENOX2
Gene Name ecto-NOX disulfide-thiol exchanger 2
Synonyms APK1; COVA1; tNOX;
Species Homo sapiens
Ensembl Gene ENSG00000165675
Encoded Proteins
ecto-NOX disulfide-thiol exchanger 2
ecto-NOX disulfide-thiol exchanger 2
ecto-NOX disulfide-thiol exchanger 2
ecto-NOX disulfide-thiol exchanger 2
ecto-NOX disulfide-thiol exchanger 2
ecto-NOX disulfide-thiol exchanger 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:130623369-130903317
Strand Reverse strand
Band q26.1
Transcripts
ENST00000370935 ENSP00000359973
ENST00000338144 ENSP00000337146
ENST00000370927 ENSP00000359965
ENST00000394363 ENSP00000377890
ENST00000432489 ENSP00000400304
ENST00000492263
ENST00000610637 ENSP00000478608
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0007624 ultradian rhythm
GO:0016049 cell growth
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.171458
RefSeq NM_001281736 NM_006375 NM_182314 XM_005262354 XM_005262355
HUGO
OMIM
CCDS CCDS14626 CCDS14627
HPRD 02234
IMGT
EMBL
GenPept
RNA Seq Atlas