Version 5.4
Homo sapiens Gene: ENOX2
Summary
InnateDB Gene IDBG-86240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENOX2
Gene Name ecto-NOX disulfide-thiol exchanger 2
Synonyms APK1; COVA1; tNOX
Species Homo sapiens
Ensembl Gene ENSG00000165675
Encoded Proteins
IDBP-86242
ecto-NOX disulfide-thiol exchanger 2
IDBP-86244
ecto-NOX disulfide-thiol exchanger 2
IDBP-86248
ecto-NOX disulfide-thiol exchanger 2
IDBP-241730
ecto-NOX disulfide-thiol exchanger 2
IDBP-381011
ecto-NOX disulfide-thiol exchanger 2
IDBP-808721
ecto-NOX disulfide-thiol exchanger 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:130623369-130903317
Strand Reverse strand
Band q26.1
Transcripts
ENST00000370935 ENSP00000359973
ENST00000338144 ENSP00000337146
ENST00000370927 ENSP00000359965
ENST00000394363 ENSP00000377890
ENST00000432489 ENSP00000400304
ENST00000492263
ENST00000610637 ENSP00000478608
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0007624 ultradian rhythm
GO:0016049 cell growth
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000031109
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.171458
RefSeq NM_001281736 NM_006375 NM_182314 XM_005262354 XM_005262355
HUGO
OMIM
CCDS CCDS14626 CCDS14627
HPRD 02234
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca