InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LZTS2

Summary

InnateDB Protein

IDBP-86873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LZTS2

Protein Name

leucine zipper, putative tumor suppressor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359240

InnateDB Gene

IDBG-86869 (LZTS2)

Protein Structure

UniProt Annotation

Function

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255HAMAP-Rule:MF_03026, ECO:0000269PubMed:17000760, ECO:0000269PubMed:17351128, ECO:0000269PubMed:17950943, ECO:0000269PubMed:18490357}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.

Disease Associations

Tissue Specificity

Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. {ECO:0000269PubMed:11709705}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0001822	kidney development
GO:0007067	mitotic nuclear division
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0051013	microtubule severing
GO:0051168	nuclear export
GO:0051255	spindle midzone assembly
GO:0072001	renal system development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1900181	negative regulation of protein localization to nucleus