InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BYSL

Summary

InnateDB Protein

IDBP-86970.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BYSL

Protein Name

bystin-like

Synonyms

BYSTIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000230340

InnateDB Gene

IDBG-86968 (BYSL)

Protein Structure

UniProt Annotation

Function

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269PubMed:17360433, ECO:0000269PubMed:17381424}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17381424}. Nucleus, nucleolus {ECO:0000269PubMed:17381424}. Note=Associated with 40S ribosomal subunits.

Disease Associations

Tissue Specificity

Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	95 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001701	in utero embryonic development
GO:0001825	blastocyst formation
GO:0001829	trophectodermal cell differentiation
GO:0007155	cell adhesion
GO:0007565	female pregnancy
GO:0008283	cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045177	apical part of cell