InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAZALD1

Summary

InnateDB Protein

IDBP-86991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAZALD1

Protein Name

Kazal-type serine peptidase inhibitor domain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359219

InnateDB Gene

IDBG-86987 (KAZALD1)

Protein Structure

UniProt Annotation

Function

Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001503	ossification
GO:0001558	regulation of cell growth
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576	extracellular region
GO:0005614	interstitial matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR002350 Kazal domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00219
PF00050
PF07648
PF07679
PF00047

PRINTS

PIRSF

PIRSF018239

SMART

SM00121
SM00280
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt